As for this invention, past production was difficult, in the nail shell and the nail floor of the nail, the suffering infection nail of the animal where the superficial characteristic true germ is infected sufficiently and production of the animal infection model are made possible, and useful evaluation method is offered to development of remedy of the difficult Osamu characteristic infection symptom such as the said nail and nail trichophytosis which uses the said animal infection model. In order the suffering infection nail of the animal which is infected the superficial characteristic true germ and to produce the animal infection model, the immunity control component was beforehand prescribed to the animal, decrease after obtaining immunity talent, the superficial characteristic true germ was inserted and the clinical sick condition where the superficial characteristic true germ is infected to the nail shell and the nail floor of the nail sufficiently by being infected, was reflected, the suffering infection nail of the animal and it is produced reproducibility to produce the animal infection model, shortly well at period.本発明は、従来作製が困難であった、爪の爪甲および爪床に、表在性真菌が十分に感染した動物の被感染爪および動物感染モデルの作製を可能とし、ならびに該爪および該動物感染モデルを用いた爪白癬などの難治性感染症の治療薬の開発に有用な評価方法を提供する。表在性真菌を感染させた動物の被感染爪および動物感染モデルを作製するため、免疫抑制成分を動物に予め投与し、免疫能を低下せしめた上で、表在性真菌を接種して感染させることにより、爪の爪甲および爪床に表在性真菌が十分に感染した臨床病態を反映した、動物の被感染爪および動物感染モデルを、短期間で再現性よく作製することができる。
