A system and method for multimodal medical treatment optimization. The system and method involve (1) providing a patient with a primary medical treatment via a first delivery system, (2) providing a patient with an adjunctive medical treatment via a second delivery system integrated with the first delivery system, and (3) adjusting at least one of the primary medical treatment and the adjunctive medical treatment as a result of the patient's response to at least one of the primary medical treatment and the adjunctive medical treatment to promote adherence/compliance, efficacy and/or other factors associated with a patient's treatment regimen.