The invention relates to antibody fusion proteins. Particularly, the invention relates to antibody fusion proteins for intra-cellular and intra-nucleus drugs delivery. The fusion protein of the invention can be used as a peptide penetration system that specifically binds to various targets for the delivery of effector peptides across a biological barrier.本發明係關於抗體融合蛋白。特定言之,本發明係關於用於胞內及核內藥物遞送之抗體融合蛋白。本發明之融合蛋白可用作肽穿透系統,其特異性地結合至各種目標以將效應肽遞送穿過生物障壁。