The present invention provides a multiple, long-term use, antimicrobial glove. The glove is formed from one or more layers of textile material with an antimicrobial silver agent incorporated therein. Optionally, the glove may also have additional antimicrobial agents incorporated therein. The glove of the present invention is capable of inhibiting microbes from proliferating on any surface of the glove, during both storage and use, which results in the prevention of malodor, discoloration, and degradation of the glove. The antimicrobial activity of the glove is sustained throughout time and throughout laundering. Additionally, the glove of the present invention is believed to be capable of imparting an antimicrobial effect to surfaces in contact with the antimicrobial glove.