MOUSE WITH DEFICIENCY OF GLUTAMATE TRANSPORTER GLAST FUNCTION

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专利权人:

发明人:

申请号：

EP04727110.1

公开号：

EP1619248B1

申请日:

2004.04.13

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The present invention provides a GLAST knockout mouse lacking the function of an endogenous glutamate transporter GLAST gene, which shows: 1) an intraocular pressure within the normal range and 2) a reduction in the number of cells in the retinal ganglions when compared with a wild-type normal mouse. Owing to the ocular properties, this knockout mouse is useful as a model for normal tension glaucoma. By using this knockout mouse, a compound useful for the treatment of normal tension glaucoma can be screened.

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中国工程科技知识中心

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