A syringe for use in a pressurized injection of a fluid includes a syringe barrel including a polymeric material having undergone expansion via blow molding. A preform for blow molding a blow molded syringe is described, the preform including a proximal end having a retention mechanism adapted to connect to the syringe to a powered injector, a distal end having a syringe outlet section, and a barrel section between the retention mechanism and the syringe outlet section, wherein the barrel section is adapted to be blow molded to form a cylindrical wall of a syringe barrel defined between the retention mechanism and the syringe outlet section.