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Aildenafil citrate crystal form O, preparation method and use thereof
专利权人:
Guikun Liu
发明人:
Guikun Liu
申请号:
US13583511
公开号:
US09663439B2
申请日:
2011.03.11
申请国别(地区):
US
年份:
2017
代理人:
摘要:
The invention provides a 1-[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d] pyridine-5-group)-4-ethoxy-benzenesulfonyl]-cis-3,5-dimethylpiperazine citrate or an Aildenafil citrate crystal form O and a preparation method thereof. And the invention also provides pharmaceutical compositions containing the Aildenafil citrate crystal form O and the use thereof in preparing drugs for treating Male Erectile Dysfunction (ED). The above crystal form O can be prepared through the steps of: dissolving a raw material, namely, the Aildenafil citrate in a mixture of distilled water and tetrahydrofuran, stirring, heating, filtering, stirring a filtrate, cooling, insulating heat, crystallizing, filtering and the like. The crystal form O can be adopted to prepare drugs with pharmaceutically acceptable excipients, so as to treat the male sexual dysfunction diseases.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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