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The Orphan Receptor modulating compounds retinoideo (ROR)
专利权人:
GLAXO GROUP LIMITED
发明人:
申请号:
ARP130101395
公开号:
AR090847A1
申请日:
2013.04.25
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Preparation procedures for drugs containing these modules, as well as procedures for the treatment of acute respiratory retransmission, metabolic and autoimmune diseases. 1. Claim 1: a formula compound (1),O select R1 from group H as agent or acceptable salt of c8332123 asphalt;C₁₋₃ alkoxy,Cf8323 and halo; R,R³ and R⁴ are H; R⁵ is C₁₋₃ alkyl;R⁶ is C₃₋₅ alkyl or -CH₂-C₃₋₄ cycloalkyl;R8311 was selected from formula residues (2) and (3) groups;each R⁸ is independently selected from the group consisting of halo, C₁₋₆ alkyl,C₁₋₆ alkoxy,C₃₋₆ cycloalkyl,CN, OH, C (O) OH, C (O) O-C₁₋₃ alkyl and CH₂OH; R⁹ is the group - (CHR¹⁰) ₛ- (X) ₜ- (CHR¹⁰) ᵘ-R¹¹;Each r83044 is independent of H, ch8323;Oh, and ch8322; Oh, X is ch832222,NH or O; R¹¹ is a heterocycloalkyl or C₃₋₆ cycloalkyl group which may not be substituted or substituted with one or more substituents independently selected from the group consisting of CH₃,Ome, oh, ch8322;; oh and halo; R is 0, 1 or 2; s is 0, 1 or 2; t is 0 or 1; u is 0, 1 or 2; provided that there are no more than two groups representing ch832304;Oh, o.c83228ohProcedimientos para su preparación, composiciones farmacéuticas que contienen estos modulares y a su uso en el tratamiento de enfermedades inflamatorias, metabólicas y autoinmunitarias mediadas por el RORg. Reivindicación 1: Un compuesto de fórmula (1), o una sal farmacéuticamente aceptable del mismo, en la que R¹ se selecciona del grupo constituido por H, alquilo C₁₋₃, alcoxi C₁₋₃, CF₃ y halo; R², R³ y R⁴ son H; R⁵ es alquilo C₁₋₃; R⁶ es alquilo C₃₋₅ o -CH₂-cicloalquilo C₃₋₄; R⁷ se selecciona del grupo constituido por los restos de fórmula (2) y (3); cada R⁸ se selecciona independientemente del grupo constituido por halo, alquilo C₁₋₆, alcoxi C₁₋₆, cicloalquilo C₃₋₆, CN, OH, C(O)OH, C(O)O-alquilo C₁₋₃ y CH₂OH; R⁹ es el grupo -(CHR¹⁰)ₛ-(X)ₜ-(CHR¹⁰)ᵘ-R¹¹; cada R¹⁰ se selecciona independientemente de entre H, CH₃, OH y CH₂OH; X es CH₂, NH u O; R¹¹ es un grupo heterocicloalquilo o cicloalquilo C₃₋
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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