Compound of Formula (I) in which: X is O or NR3； wherein R3 is: H, C (1-6) alkyl, CH2CF3, C (1-6) alkyl OH, C (2-6) alkenyl, CH2C (2-6) alkenyl, CH2C (1-6) alkyl , C (O) C (1-6) alkyl, CONH2, CONH C (1-6) alkyl, SONH2, CH2Ph, CH2heteroaryl, CH2heterocyclyl, CH2cycloalkyl, C (3-6) cycloalkyl, or SO2C (1-2) alkyl； wherein said heteroaryl, heterocyclyl or cycloalkyl may be optionally substituted with up to three substituents selected from the group consisting of: F, OCH3, CH3 and OH； Y1 and Y2 are CH or N, provided that neither Y1 nor Y2 is N； Z is O, CH2, S, S (O), ** Formula ** SO2, or a direct link； wherein Ra and Rb are independently selected from the group consisting of: H, OH, F, CH3, CF3, OCF3 and OCH3； R1 is ** Formula ** pyridyl, pyridyl-N-oxide, pyrimidyl, pyrazolyl, indolyl, thiazolyl, benzo [1,3] dioxol-5-yl, pyrazolyl, oxazolyl, isoxazolyl, imidazolyl, phenyl, thiazolyl, isothiazolyl, 3 -H-thiazol-2-onyl, benzooxazolyl, furyl, [1,2,4] oxadiazolyl, [1,3,4] thiadiazolyl, cycloalkyl C (4-7), C (1-6) alkyl, C ( 1-4) OH, CH2Calkenyl C (3-6), CH2Calkyl C (1-4), CH2C (O) NH2, CO2Calkyl C (1-4), -CN, C (O) NH2, C (O) NHCH2CH2OH , OTBS, OH, C (1-4) alkyl, C (3-6) alkenyl, NH2, NHBOC or pyridonyl； wherein said pyridyl, pyridyl-N-oxide, pyrimidyl, pyrazolyl, indolyl, thiazolyl, benzo [1,3] dioxol-5-yl, pyrazolyl, oxazolyl, isoxazolyl, imidazolyl, phenyl, thiazolyl, isothiazolyl, 3-H- thiazol-2-onyl, benzooxazolyl, furyl, [1,2,4] oxadiazolyl, [1,3,4] thiadiazolyl, cycloalkyl C (4-7), C (1-6) alkyl or pyridonyl, may be optionally substituted with one or two substituents, independently selected from the group consisting of: CH2C (O) NH2, C (1-4) alkoxy, Occycloalkyl C (3-6), OCH2CF3, OCH2Ph, F, CN, Cl, OCF3, CF3, CH2CN, C (1-4) alkyl, CH2CF3, N (C (1-4) alkyl) 2, C (1-4) alkyl OH, Si (CH3) 3, -C≡CH SCH3, S (O) CH3 , SO2CH3, pyrrolidinyl, OH, NH2, NHCN, CO2H, CONH2, NHCO2alkyl C (1-4), N (SO2CH3) 2, NHSO2CH3, NHC (O) CF3, NHalkyl C (1-4), NHCO2H, NHCO2alkyl C ( 1-4), NHC
