PREDICTION OF RESPONSIVENESS TO TREATMENT WITH IMMUNOMODULATORY THERAPEUTICS AND METHOD OF MONITORING ABSCOPAL EFFECTS DURING SUCH TREATMENT

• 收藏
• 分享

专利权人:

SLOAN KETTERING INSTITUTE FOR CANCER RESEARCH

发明人:

LESOKHIN, ALEXANDER, M.,WOLCHOK, JEDD, D.

申请号：

EP13752111

公开号：

EP2817619A4

申请日:

2013.02.22

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Efficacy of a therapeutic to enhance antitumor immunity in a patient is predicted, where the therapeutic is one that targets an immunomodulatory leukocyte membrane protein (ILMP) to enhance immune activity. Peripheral blood sample from the patient is tested for levels of monocytes having specific cell surface markers (CD14+, HLA-DRlow) prior to treatment. Low levels of monocytes of this type (PBM14+HLA-DRlow) indicate a greater likelihood of therapeutic efficacy. In specific exemplary embodiments of the invention, the therapeutic is an antibody to CTLA4, such as ipilimumab or tremelimumab.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/