SAMUEL DAVIDS,JOANNE BRUNO,MITCHELL GOLDFARB,THOMAS H. ALDRICH,PETER C. MAISONPIERRE,CZESLAW RADZIEJEWSKI,PAMELA F. JONES,GEORGE D. YANCOPOULOS
申请号：
ZA958444
公开号：
ZA958444B
申请日:
1995.10.06
申请国别(地区):
ZA
年份:
2014
代理人:
摘要：
The present invention provides for an isolated nucleic acid molecule encoding a human TIE-2 ligand. In addition, the invention provides for a receptor body which specifically binds a human TIE-2 ligand. The invention also provides an antibody which specifically binds a human TIE-2 ligand. The invention further provides for an antagonist of human TIE-2. The invention also provides for therapeutic compositions as well as a method of blocking blood vessel growth, a method of promoting neovascularization, a method of promoting the growth or differentiation of a cell expressing the TIE-2 receptor, a method of blocking the growth or differentiation of a cell expressing the TIE-2 receptor and a method of attenuating or preventing tumor growth in a human.
