ABEL ULRICH,KUBAS HOLGER,MEYER UDO,ZEMRIBO RONALDS
申请号：
ARP120101679
公开号：
AR086371A1
申请日:
2012.05.11
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Multicycle derivatives, pharmaceutically acceptable salts thereof, and processes for the preparation of these compounds. 1. The compound is a mGluR5 modulator, so it is helpful to control and prevent acute and / or chronic nervous disorders 1: a compound selected from formula (1) where n represents 1 or 2； R1 stands for C1-6 tar, which can be selectively replaced by one or more substitutes selected from halogen, trifluoro-2, trifluoro-2, alkoxy-c1-6, ammonia, hydroxy, butadiene-6 and di - (C1-6 tar) aminobenzene, cyclomethane-c3-6, isopropene and arilo,heteroaryl, C1-6 alkylsulfonyl which may be optionally substituted with one or more substituents selected from halogen, trifluoromethyl, trifluoromethoxy, C1-6 alkoxy, amino, hydroxy, C1-6 alkylamino, and di (C1-6 alkyl) amino, C3 cycloalkylsulfonyl -6, -C (O) R4, or a remainder of formula (2)；R2 stands for arilo, heteromorphism, c3-12 cyclopropyl or isomerization； R3 stands for H, F, oh, alcoxi C1-6； R4 stands for C1-6 tar, which can be replaced by one or more alternatives selected from halogen, trifluoroenzene, trifluoroactane sulfonic acid, alkoxy C1-6, ammonia, water Xi, C1-6 rental and di (tar C1-6) amine, Epoxy C3-6, isocyclohexane, epoxy C1-6 may be replaced by one or more alternatives selected from halogen, sulfur trifluoride, sulfur trifluoride, toxi, propoxyc1-6, ammonia, hydroxyl, rental C1-6, and di (C1-6 tar) amino, o-nr5r6, R5, and R6, which may be the same or different,They represent h or C1-6 tar and can be replaced by one or more substitutes selected from halogen, trifluoro-1, trifluoro-2, alkoxy C1-6, amino, hydroxy, rental C1-6 and diazo (C1-6 tar) amino or R5 and R6, forming a 3-7 member ring together with the attached nitrogen atoms. Saturated or unsaturated. In this case, the optional ring can contain one or two heteroatoms selected from sulfur, oxygen and nitrogen. In this case, one or more substitutes selected from halogen, sulfur trifluoride, sulfur trifluoride, epoxy C1-6, ammonia water and h
