Hamel, Josée,Couture, France,Brodeur, Bernard R.,Martin, Denis,Ouellet, Catherine,Tremblay, Mireille,Charbonneau, Annie,Vayssier, Catherine
申请号：
ES09159896
公开号：
ES2588023T3
申请日:
2001.10.02
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A vaccine composition comprising a pharmaceutically acceptable carrier or diluent and an isolated polypeptide that is chosen from: (a) an isolated polypeptide consisting of an amino acid sequence having an identity of at least 85% with the amino acid sequence set out in SEQ ID NO: 10； (b) an isolated polypeptide consisting of an amino acid sequence that has an identity of at least 90% with the amino acid sequence set forth in SEQ ID NO: 10； (c) an isolated polypeptide consisting of an amino acid sequence that has an identity of at least 95% with the amino acid sequence set forth in SEQ ID NO: 10； (d) an isolated polypeptide consisting of the amino acid sequence set forth in SEQ ID NO: 10； (e) an isolated polypeptide that is an analogue of a polypeptide consisting of the amino acid sequence SEQ ID NO: 10, in which the analog has less than 20 substitutions or deletions of amino acid residues of SEQ ID NO: 10； (f) an immunogenic fragment consisting of at least 15 contiguous amino acids of the amino acid sequence set forth in SEQ ID NO: 10, in which the immunogenic fragment may give rise to an immune response against Haemophilus influenzae； (g) the polypeptide isolated from (a), (b), (c), (d), or (e), in which the Met moiety of the N-terminus has been removed； and (h) the polypeptide isolated from (a), (b), (c), (d), or (e), in which the secretory amino acid sequence has been removed, in which the isolated polypeptide can give rise to to an immune response against Haemophilus influenzae.Una composición de vacuna que comprende un vehículo o diluyente farmacéuticamente aceptable y un polipéptido aislado que se escoge de entre: (a) un polipéptido aislado que consiste en una secuencia de aminoácidos que tiene una identidad de al menos el 85% con la secuencia de aminoácidos expuesta en SEQ ID NO: 10； (b) un polipéptido aislado que consiste una secuencia de aminoácidos que tiene una identidad de al menos el 90% con la secuencia de aminoácidos expuesta en SEQ ID NO: 10； (c) un
