AKIN H. DAVULCU,ALBERT J. DELMONTE,CHAO HANG,CHRISTINA ANN RISATTI,KENNETH J. FRAUNHOFFER,KENNETH J. NATALIE JR.,WENHAO HU,ZHINONG GAO
申请号：
BR112015000714
公开号：
BR112015000714A2
申请日:
2013.07.16
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Patent and Methods of Preparation of (4bs, 5ar) -12-cyclohexyl-n- (n, n-dimethylsulfamoyl) -3-methoxy-5a - ((1r, 5s) -3- methyl-3,8-diazabicyclo [3.2.1] octane-8-carbonyl) -4b, 5,5a, 6-tetrahydrobenzo [3,4] cyclopropa [5,6] azepino [1,2-a] indole Carboxamide ". The present invention relates to methods and intermediates for the preparation of (1ar, 12bs) -8-cyclohexyl-11-fluoro-n - ((1-methylcyclopropyl) sulfonyl) -1a - ((3-methyl-3 , 8-diazabicyclo [3.2.1] oct-8-yl) carbonyl) -1,1a, 2,12b-tetrahydrocyclopropa [d] indolo [2,1-a] [2] benzazepine-5-carboxamide (formula i) including pharmaceutically acceptable salts. The compound has activity against the hepatitis c virus (hcv) and may be useful in treating those infected with hcv.resumo patente de invenção: "métodos e intermediários para a preparação de (4bs,5ar)-12-ciclo-hexil-n-(n,n-dimetilsulfamoil)-3-metóxi-5a-((1r,5s)-3-metil-3,8-diazabiciclo [3.2.1]octano-8-carbonil)-4b,5,5a,6-tetra-hidrobenzo [3,4]ciclopropa[5,6]azepino[1,2-a]indol-9-carboxamida". a presente invenção refere-se a métodos e intermediários para a preparação de (1ar,12bs)-8-ciclo-hexil-11-fluoro-n-((1-metilciclopropil)sulfonil)-1a-((3-metil-3,8-diazabiciclo[3.2.1]oct-8-il)carbonil)-1,1a,2,12b-tetra-hidrociclopropa[d]indolo[2,1-a][2]benzazepina-5-carboxamida (fórmula i), incluindo sais farmaceuticamente aceitáveis. o composto possui atividade contra o vírus da hepatite c (hcv) e pode ser útil no tratamento daqueles infectados com hcv.
