DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET

• 收藏
• 分享

专利权人:

发明人:

申请号：

EP09738409.3

公开号：

EP2283151B1

申请日:

2009.05.01

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a fungal DHODH protein and determining whether the candidate substance binds or modulates the DHODH protein, wherein binding or modulation indicates that the candidate substance is an antifungal agent. Specific examples concern Aspergillus fumigatus and Candida albicans DHODH proteins. DHODH inhibitors with a Quinazolinone core are also disclosed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/