DIFFERENTIAL DRUG DEVELOPMENT ASSOCIATES LLC;SOV THERAPEUTICS
发明人:
DHINGRA, OM,BERNSTEIN, JAMES, S.
申请号：
EP13877592
公开号：
EP2968137A4
申请日:
2013.07.03
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
A SEDDS or SMEDDS or SNEDDS formulation for drug delivery of a lipophilic therapeutic agent, providing enhanced modulation of solubility, stability, absorption, metabolism, and/or pharmacokinetic profile of the therapeutic agent by formulation with a lipophilic surfactant, a hydrophilic surfactant, one or more solubilizers and, optionally, digestible oils, resulting in higher bioavailability of the therapeutic agent administered to a subject in need of such therapeutic agent. Also described are pharmaceutical compositions containing the formulations and methods of making and methods of using the formulations and pharmaceutical compositions. Formulations of the disclosure can be constituted to minimize the synthesis of dihydrotestosterone when the therapeutic agent includes testosterone or testosterone esters.
