William N. C. Sun;Cecily R. Y. Sun;Michael S. C. Fung
发明人:
Michael S. C. Fung,William N. C. Sun,Cecily R. Y. Sun
申请号:
US13081203
公开号:
US08124090B2
申请日:
2011.04.06
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to factor D inhibitors, which bind to factor D and block the functional activity of factor D in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like Fab, F(ab′)2 and Fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds. A monoclonal antibody which bound to factor D and blocked its ability to activate complement was generated and designated 166-32. The hybridoma producing this antibody was deposited at the American Type Culture Collection, 10801 University Blvd., Manassas, Va. 20110-2209, under Accession Number HB-12476.