REGUEIRO-REN ALICIA,SWIDORSKI JACOB,SIT SING-YUEN,CHEN YAN,CHEN JIE,MEANWELL NICHOLAS A.
申请号：
NZ63140813
公开号：
NZ631408A
申请日:
2013.02.13
申请国别(地区):
NZ
年份:
2015
代理人:
摘要：
Disclosed are C-3 cycloalkenyl triterpenoid compounds of formula (I)-(IV), wherein the substituents are as defined in the specification. The compounds possess antiviral activity and are HIV maturation inhibitors useful for the treatment of HIV and AIDS. An example of a compound of formula (I)-(IV) is: 2-(4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-5a,5b,8,8,11apentamethyl-3a-((2-(4-(methylsulfonyl)piperidin-1-yl)ethyl)amino )-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1Hcyclopenta[a]chrysen-9-yl)cyclohex-3-en-1-yl)acetic acid
