A COMPOUND OF THE FOLLOWING GENERAL FORMULA [I]: WHEREIN EACH SYMBOL HAS THE SAME MEANING AS DEFINED HEREIN, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, OR A SOLVATE THEREOF, AND A PHARMACEUTICAL USE OF THE SAME IN TREATING ORGAN TRANSPLANT REJECTION, GRAFT VERSUS HOST REACTION AFTER TRANSPLANTATION, AUTOIMMUNE DISEASE, ALLERGIC DISEASE AND CHRONIC MYELOPROLIFERATIVE DISEASE.