The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.本發明提供治療與CD123表現相關聯之疾病之組合物及方法。本發明亦關於特異於CD123之嵌合抗原受體(CAR)、編碼其之載體及包含該CD123 CAR之重組細胞。本發明亦包括投與表現包含CD123結合域之CAR之遺傳修飾細胞的方法。