A drug that includes) nitrogenous Heterocyclic compounds FUSED, modulators of cen and CPE, and (b) a compuestyo or Antibody to influenza activity； and its use for influenza.
(a) The medical characteristics of a behavior represented by formula (I)its pharmaceutically acceptable salt or a solvate thereof wherein P is hydrogen or a group to form a prodrug A1 is CR1AR1B S or O A2 is CR2AR2B S or O A3 is CR3AR3B S or O A4 is each independently CR4AR4B S or O the number of hetero atoms R4B are each independently hydrogen halogen alkyl or the like R3A and R3B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle n is any integer of 1 to 2 and R1 is or the like is combined with<；p>；A medicament characterized in that (A) a compound represented by the formula (I): , its pharmaceutically acceptable salt, or a solvate thereof, wherein P is hydrogen or a group to form a prodrug； A1 is CR1AR1B, S or O； A2 is CR2AR2B, S or O； A3 is CR3AR3B, S or O； A4 is each independently CR4AR4B, S or O； the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1 and carbon atom adjacent to A4 is 1 or 2； R1A and R1B are each independently hydrogen, halogen, alkyl or the like； R2A and R2B are each independently hydrogen, halogen, alkyl, or the like； R3A and R3B are each independently hydrogen, halogen, alkyl, or the like； R4A are each independently hydrogen, halogen, alkyl, or the like； R4B are each independently hydrogen, halogen, alkyl, or the like； R3A and R3B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle； n is any integer of 1 to 2； and R1 is or the like, is combined with (B) compound(s) having an anti-influenza activity, its pharmaceutically acceptable salt or a solvate thereof and/or an antibody having anti-influenza activity, is useful for treating or preventing influenza.<；/p>；
