A wrist-hand-finger orthosis (100, 200) comprises a splint (110, 210) comprising a supporting splint section (120, 220) extending over the MCP joints and at least a greater portion of the fingers. The supporting splint section (120, 220) has a dorsal main surface (126, 226) adapted to face the palmar side of the hand. A wrist and forearm splint section (130, 230) is connected to or integral with the supporting splint section (120, 220). Inflatable bladders (140, 240 150, 250) are arranged on the dorsal main surface (126, 226) at a MCP portion (122, 22) and a phalanx portion (124, 224) of the supporting splint section (120, 220) to be aligned with the MCP joints of the hand and the phalanges of fingers, respectively. The orthosis (100, 200) is particularly useful for human subjects having suffered from neurological diseases or cerebrovascular accident (CVA).