COMPOSITIONS COMPRENANT DE LA LCAT MODIFIEE ET LEUR UTILISATION

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专利权人:

AMGEN INC.

发明人:

KAYSER, FRANK,LABELLE, MARC,SHAN, BEI,ZHANG, JIAN,ZHOU, MINGYUE

申请号：

CA2787343

公开号：

CA2787343C

申请日:

2007.06.26

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The invention provides compounds, pharmaceutical compositions and methodscomprising modifiedLCAT for treating atherosclerosis, inflammation, thrombosis and otherconditions and for decreasing orprevention of accumulation of cholesterol in a subject. The modified LCAThaving a replacement of theamino acid residue 31 by a cysteine residue. The cysteine residue beingmodified by replacing the thiolhydrogen with 3-pyrazinyl-2-carbonitrile.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/