AUH, JIN,HAN, CHANG KYUN,한창균,JEONG, HYEON GUN,정현근,KIM, YANG JOONG,김양중,KIM, JONG GEAL,김종걸,LEE, JUNG HWA,이정화,HA, NAM SUNG,하남성
申请号：
KR1020110034022
公开号：
KR1020120116545A
申请日:
2011.04.13
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
PURPOSE: An aceclofenac containing release control tablet is provided to show anti-inflammatory effects by taking the tablet once a day and to drastically enhance administration convenience.CONSTITUTION: A release control tablet contains aceclofenac as active ingredient and has slow release layer and rapid release layer which are adjacent to each other. The rapid release layer comprises 25-35 wt% of aceclofenac, 3-6 wt% of disintegrant of croscarmellose sodium, crospovidone or starch sodium gluconate. 10-14 wt% of D-mannitol, lactose or excipient of microcrystalline cellulose, 0.5-1.5 wt% of hydroxypropyl cellulose, povidone, binder of gelatin, or methyl cellulose, and 1-2 wt% of hard silicon dioxide, lubricant of magnesium stearate or talc. The slow-release layer comprises 28-38 wt% of acroclofenac, 6-10 wt% of Hypromellose and 0.7-9 wt% of polyethylene oxide, 4-7 wt% of microcrystalline cellulose, corn starch, or refractory excipient of the potato starch, 0.5-1.5 wt% of hydroxypropyl cellulose, povidone, binder of gelatin or methyl cellulose, and 1-2 wt% of hard silicon dioxide, lubricant of magnesium stearate and talc based on the weight of the tablet.COPYRIGHT KIPO 2013[Reference numerals] (AA) Experiment result of elution rate of practical example 1-3 (BB) 0.5 hour (CC) 1 hour (DD) 2 hours (EE) 5 hours (FF) 8 hours (GG) 12 hours (HH) 24 hours (II) Practical example 1 (JJ) Practical example 2 (KK) Practical example 3본 발명은 아세클로페낙 함유 방출제어형 정제에 관한 것으로서, 좀더 상세히 설명하면 서로 인접한 속방출층과 서방출층을 갖는 다층 구조로 이루어지되 상기 서방출층에는 서방출성 기재로서 친수성 고분자 물질인 히프로멜로오스와 폴리에칠렌옥시드가 포함되어 있어서, 종래의 방출제어형 기재에 비해 정제 자체의 크기가 훨씬 작으면서도 1일 1회 복용이 가능하도록 설계된 아세클로페낙 함유 방출제어형 정제에 관한 것이다.
