Disclosed is a thermoformed pharmaceutical dosage form (such as in tablet form) with controlled release of a pharmacologically psychotropically active compound (A) (such as tapentadol) contained therein, the pharmaceutical dosage form having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2； wherein a portion of the surface of the pharmaceutical dosage form is convex, another portion of its surface is concave； the content of the pharmacologically active compound (A) is at least 0.5 wt % based on the total weight of the dosage form； the dosage form contains polymer (C), which is a polyalkylene oxide (and preferably a polyethylene oxide) having a weight average molecular weight of at least 200,000 g/mol； the content of polymer (C) is at least 15 wt. %, based on the total weight of the dosage form； the pharmacologically active compound (A) is embedded in the polymer (C)； and the pharmaceutical dosage form is adapted for oral administration once daily or twice daily.
