Eduardo Marban,Ronald A. Li,Suk-Ying Tsang,Heecheol Cho,Tian Xue
申请号：
US14159919
公开号：
US20140199280A1
申请日:
2014.01.21
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to novel compositions and methods to induce, and/of modulate bio-electrical rhythms (e.g. in cardiac, neuronal and pancreatic cells) by fine-tuning the activity of HCN-encoded pacemaker channels via a novel protein- and genetic-engineering approach to augment or attenuate the associated physiological responses (e.g. heart beat, neuronal firing, insulin secretion, etc) for achieving various therapeutic purposes (e.g. sick sinus syndrome, epilepsy, neuropathic pain, diabetes, etc).
