GUIDO BOLD,JORG FREI,PETER TRAXLER,KARL-HEINZ ALTMANN,HELMUT METT,DAVID RAYMOND STOVER,JEANETTE WOOD
申请号：
BR9807685
公开号：
BR9807685B1
申请日:
1998.02.11
申请国别(地区):
BR
年份:
2013
代理人:
摘要：
The invention relates to compounds of formula I,wherein r is 0 to 2, n is 0 to 2； m is 0 to 4； R1 and R2 (i) are in each case a lower alkyl, or (ii) together form a bridge in subformula I*or (iii) together form a bridge in subformula I**wherein one or two of the ring members T1, T2, T3, and T4 are nitrogen, and the remainder are in each case CH； A, B, D, and E are N or CH, wherein not more than 2 of these radicals are N； G is lower alkylene, acyloxy- or hydroxy-lower alkylene, -CH2-O-, -CH2-S-, -CH2-NH-, oxa, thia, or imino； Q is methyl； R is H or lower alkyl； X is imino, oxa, or thia； Y is aryl, pyridyl, or (un)substituted cycloalkyl； and Z is mono- or disubstited amino, halogen, alkyl, substituted alkyl, hydroxy, etheritied or esterified hydroxy, nitro, cyano, carboxy, esterified carboxy, alkanoyl, carbamoyl, N-mono- or N,N-disubstituted carbamoyl, amidino, guanidino, mercapto, sulfo, phenylthio, phenyl-lower alkylthio, alkylphenylthio, phenylsulfinyl, phenyl-lower alkylsulfinyl, alkylphenylsulfinyl, phenylsulfonyl, phenyl-lower alkylsulfonyl, or alkylphenylsulfony； and wherein the bonds characterized by a wavy line are either single or double bonds； or an N-oxide of said compound with the stipulation that, if Y is pyridyl or unsubstituted cycloalkyl, X is imino, and the remaining radicals are as defined, then G is selected from the group comprising lower alkylene, -CH2-O-, -CH2-S-, oxa and thia； or a salt thereof. The compounds inhibit angiogenesis.
