CHAKRABARTY, Suravi,FLAHERTY, Patrick T.,MONLISH, Darlene,CAVANAUGH, Jane E.,BUROW, Matthew E.,ELLIOTT, Steven,HOANG, Van T.
申请号：
EP14843462
公开号：
EP3043790A4
申请日:
2014.09.11
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.
