TARRANT, LAURENCE, B.,SVRLUGA, RICHARD, C.,KIRKPATRICK, SEAN, R.
申请号：
EP12825367
公开号：
EP2747711A4
申请日:
2012.08.22
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration.
