Compounds are provided that are modulators of the C5a receptor. The compounds are substituted piperidines and are useful in pharmaceutical compositions, methods for the treatment of diseases and disorders involving the pathologic activtation of C5a receptors.本發明提供一種化合物,其為C5a受體之調節劑。該等化合物為經取代之哌啶且適用於治療涉及C5a受體之病理性活化之疾病及病症的醫藥組合物及方法中。