Disclosed are a novel thiazole-containing benzophenone derivative representedby formula 1, and an isomer thereof, a pharmaceutically acceptable saltthereof, a hydratethereof and a solvate thereof, a pharmaceutical composition comprising thederivative, ause of the derivative as therapeutic agent and a method for preparing thederivative. Thebenzophenone thiazole derivatives inhibit formation of microtubules andeliminateactively proliferating cells of malignant tumors to control general cellproliferation. Informula 1, R, R1 and R2 are defined as above.
