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3. SIRP - architecture of alpha domain or its variants. (Divisional request 201800340).
专利权人:
ALX ONCOLOGY INC.
发明人:
PONS JAUME,DEMING LAURA,GOODMAN COREY,SIM BANG JANET,KAUDER STEVEN ELLIOT,WAN HONG,KUO TRACY CHIA-CHIEN
申请号:
CL2020000530
公开号:
CL2020000530A1
申请日:
2020.03.04
申请国别(地区):
CL
年份:
2020
代理人:
摘要:
T. lt; P gt; this note; oacute; n introduces architecture and polyacrylate; eacute; pat and amp impregnants; Iacute; se amp regulator; ntilde; ales (SIRP - (x) they are amp; uacut; tiles, for example,If you have already registered, please log in first.One C amp; eacute; Lula cancerosa or one C amp; eacute; Lula de la sistema immune system,Increase the blood sugar of C amp; eacute; Lula Diana, eliminate C amp; eacute; immune cells, such as lymphocyte regulation, eliminate C amp; eacute; cancer cells, and treat diseases (e.g., research and development)C amp; Aacute; NCER; or any combination of CI amp; s; oacute; of a subject. The architecture of sirp-a includes a DL domain from sirp-a to sirp-a variant, which connects to CD47 and M amp; Aacute; s, which is larger than that of wild sirp-a. The baptism of building polar amp; eacute; sirp-a includes a fusion sirp-a DL, which merges with Mon amp; oacute; albumina S amp; eacute; rich people (HSA), which belongs to Fc domain name only,One P amp; eacute; uni amp; impregnation; oacute; n a alumina or pol amp; Iacute; pure polyethylene (PEG). The components provided in this document include (I) a polypropylene and acrylonitrile; eacute; polypropylene and acrylonitrile including a DL variant; Iacute; se amp regulator; ntilde; ales a (sirp-a) and (II) an antibody / P gt; and;<;p>;LA PRESENTE DESCRIPCIÓ;N PRESENTA CONSTRUCCIONES Y POLIPÉ;PTIDOS DE LA PROTEÍ;NA REGULADORA DE SEÑ;ALES (SIRP-(X) QUE SON Ú;TILES, P. EJ., PARA DIRIGIRSE A UNA CÉ;LULA (P. EJ., UNA CÉ;LULA CANCEROSA O UNA CÉ;LULA DEL SISTEMA INMUNITARIO), AUMENTAR LA FAGOCITOSIS DE LA CÉ;LULA DIANA, ELIMINAR CÉ;LULAS INMUNITARIAS TALES COMO LINFOCITOS T REGULADORES, DESTRUIR CÉ;LULAS CANCEROSAS, TRATAR UNA ENFERMEDAD (P. EJ., UN CÁ;NCER) EN UN SUJETO, O CUALQUIER COMBINACIÓ;N DE ESTAS OPCIONES. LAS CONSTRUCCIONES DE SIRP-A INCLUYEN UN DOMINIO DL DE SIRP-A DE AFINIDAD
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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