A surgical endoscopic instrument with detachable end tool as a clamp is provided. The instrument comprises a clamp, removably connected by a coupling to an elongated shaft, this comprising two concentric tubes, which can rotate about each other, connected to a rotating element, that is attached to a housing, inside which a push-pull rod, driven by a handle, transmits the surgeons commands, leading to the actuating of the end tools jaws, as well as the clamp detachment/retrieving, from/to the elongated shaft, by operating the coupling, given by the rotation of the concentric tubes about each other, thus resulting in the detachment/attachment of clamp with its jaws blocked in its given position at the time of detachment.