EXPRESSION GENIQUE A BASE D'ARNM POUR LA PERSONNALISATION DE LA THERAPIE ANTICANCEREUSE D'UN PATIENT PAR UN ANTAGONISTE DE MDM2

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专利权人:

F. HOFFMANN-LA ROCHE AG

发明人:

CHEN, GONG,DANGL, MARKUS,GEHO, DAVID,NICHOLS, GWEN,ZHONG, HUA

申请号：

CA2912547

公开号：

CA2912547A1

申请日:

2014.07.02

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

The present application discloses a method to predict responsiveness of a patient, with cancer, to treatment with an MDM2 antagonist of formulae I, II and III as disclosed herein, said method comprising measuring m RNA expression levels of at least MDM2, preferably of a four gene panel comprising MDM2, XPC, BBC3 and CDKN2A, as a biomarker for predicting the response.

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中国工程科技知识中心

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