STROHBACH, Joseph Walter,LIMBURG, David Christopher,MATHIAS, John Paul,THORARENSEN, Atli,DENNY, Rajiah Aldrin,ZAPF, Christoph Wolfgang,ELBAUM, Daniel,GAVRIN, Lori Krim,EFREMOV, Ivan Viktorovich
申请号：
PE2019001045
公开号：
PE20200739A1
申请日:
2017.11.17
申请国别(地区):
PE
年份:
2020
代理人:
摘要：
LSE refers to a formula compound (I) or a pharmaceutically acceptable salt, where W is phenyl, selectively combined with cyclopentanyl of 5 to 6 members or non cyclopentyl of 5 to 6 members； and is a non-n-propyl conjugate of 5 members including 1 to 2 members. Three to four heteromorphic organisms were selected from n, O and S (o) n groups； Z was selected from phenyl, C1-C6 tar and C3-C7 cyclopropyl compounds； R1a and r1b were selected from h-h-oh, halo, C1-C6 tar, etc.； R2 was selected from group h-h. 2. Halo-cn, etc；R3 and R4 were selected from the group containing - H, C1-C6 and C1-C6 halides. The most popular compounds are 4-amino-5 - [2 - (fluoromethyl) pirimidin-5-il-5-il] - [2 - [2 - (difluorooctane sulfonic acid]] - 7 - (1 - (s) - 1 - [1 - (2-2-fluoro-phenol-4-il-1] ethyl] 1-1 - [h-pirazol-4-4-4-1] 1-7-7-7-7-7-7-7 - [1 - (1 - [1 - [1] [1] 1 - [1 - [1] 1 - [2 [2-1] 1 - [2-1 [1] 1] 1 - [2-1] [1] 1 - [1 - [1 - [1 [2-1 [2-1] 1 [1] 1 [1] 1 [1 [1 [1] 1 [1 [1 [1 1 - [1] - 1 - [1 - [1 - [1 - [1 - [1]] - 1 - [1 - [1] - 7 h-pirrolo [2, 3-d] pirimina-6-carbonitilo et al. These compounds help to enhance the transmembrane conduction regulation of cystic fibrosis (CFTR).It is used in the treatment of cyst, asthma, bronchitis and chronic obstructive pulmonary disease (EPOC). It also refers to pharmacological composers that contain this compound.LSe refiere a un compuesto de formula (I) o una sal farmaceuticamente aceptable del mismo, en donde W es fenilo, que esta opcionalmente fusionado con un cicloalquilo de cinco a seis miembros o un heterocicloalquilo de cinco a seis miembros, entre otros； Y es un heteroarilo de cinco miembros que comprende uno, dos, tres o cuatro heteroatomos seleccionados del grupo que consiste en N, O y S(O)n； Z se selecciona del grupo que consiste en fenilo, alquilo C1-C6, cicloalquilo C3-C7, entre otros； R1a y R1b se seleccionan cada uno independientemente del grupo que consiste en -H, -OH, halo, alquilo C1-C6, entre otros； R2 se selecciona del g
