BARTKOVITZ, DAVID JOSEPH,CHU, XIN-JIE,LUK, KIN-CHUN THOMAS
申请号：
CA2694666
公开号：
CA2694666C
申请日:
2008.08.04
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention is directed to pyrazolo[3,4-d]pyrimidine derivatives ofthe formula (I), andpharmaceutically-acceptable salts and esters thereof, wherein R, Ring A, L,and Ring B are asdescribed herein. These compounds and their pharmaceutically-acceptable saltsand esters inhibitRaf kinase and have antiproliferative activity. As such, they are useful inthe treatment or controlof proliferative disorders such as cancer, in particular solid tumors, moreparticularly breasttumor, colon tumor, lung tumor, prostate tumor, and melanoma. Also disclosedare acomposition and a unit dose formulation comprising such a compound, or apharmaceutically-acceptable salt or ester thereof, methods for making suchcompounds, and methods for usingsuch compounds, or their pharmaceutically-acceptable salts or esters, in thetreatment ofproliferative disorders.
