Edward N. Hill,Frederick D. Sancilio,Robert R. Whittle
申请号：
US13167350
公开号：
US08227454B2
申请日:
2011.06.23
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Novel estrogenic compounds of Formula I are provided.wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R1 is selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, R1 does not exist R2 is lower alkyl R3 may be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters and R4 through R13 may independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and R14 is selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When R1 is hydroxy, the hydroxy or ester substituent may have either an α or a β orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.
