The present disclosure provides anti-CD22 antibody-drug conjugates comprising a hydrophilic self-immolative linker. The present disclosures further provide compositions and methods for treating cancers.本揭示內容提供包含親水性自我犧牲連接子之抗CD22抗體藥物複合體。本揭示內容進一步提供用於治療癌症之組成物及方法。