ANDREMONT ANTOINE,DE GUNZBURG JEAN,LESCURE FRANÇOIS
申请号:
IN6549/CHENP/2011
公开号:
IN2011CN06549A
申请日:
2011.09.13
申请国别(地区):
IN
年份:
2013
代理人:
摘要:
Oral drug delivery formulations which specifically administer antibacterial agents to the ileum caecum and/or the colon without significant administration elsewhere in the gastrointestinal tract are disclosed. The formulations include as actives a combination of a macrolide or aminoglysoside or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.