丙啶磺醯胺類化合物及其使用方法农业专利-农业学术服务平台

专利权人:: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.;LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.;CENTAURUS BIOPHARMA CO., LTD.

发明人:: ZHU, LI,祝力,YANG, YANQING,杨艶青,楊艶青,DAI, LIGUANG,戴丽光,戴麗光,DUAN, XIAOWEI,段小伟,段小偉,YANG, ZHAO,杨钊,楊釗,ZHANG, HUI,张慧,張慧,HU, YUANDONG,胡远东,胡遠東,PENG, YONG,彭　勇,HAN, YONGXIN,韩永信,韓永信,ZHAO, RUI,赵锐,趙銳,TIAN, XIN,彭勇

摘要：: An iridinesulfonamide compound having isocitrate dehydrogenase 1 (IDH1) inhibitory activity, pharmaceutically-acceptable salts, solvates or hydrates thereof, a pharmaceutical composition, as well as use of the compound or the pharmaceutically-acceptable salts, solvates or hydrates thereof, and the pharmaceutical composition thereof in treating IDH1 mutation-induced cancers.本發明提供丙啶磺醯胺類化合物及其使用方法，具體涉及如式I所示的新的具有異檸檬酸脫氫酶1(IDH1)抑制活性的化合物或其藥學上可接受的鹽、溶劑化物或水合物、其藥物組合物。本發明還涉及所述化合物或其藥學上可接受的鹽、溶劑化物或水合物和其藥物組合物在治療IDH1突變誘發的癌症中的用途。