A device for disinfection by means of ionic current, said device (100) being characterized in that it comprises a main body provided with a data processing unit (110) suitable for feeding a constant current generator (120) with a signal of generation of an electric current fed to a couple of electrodes (131, 132) electrically correlated thereto and furthermore comprising an user interface device (140) configured for allowing to select a determined pathology among a plurality of pathologies stored in advance into a memory (150) electrically connected with said data processing unit (110), wherein for each pathology of said plurality of pathologies is in advance stored in said memory an interval of values of electric current and/or of electric charge and/or a specific value of electric current and/or of electric charge that said constant current generator (120) shall feed during said therapy, and wherein said couple of electrodes (131, 132) comprises a first electrode of an elongated type (131) suitable to be introduced or anyway laid on a portion of human body infected or inflamed, said portion being a bone or tooth or respective cavities thereof, and a second electrode (132) suitable to be grasped by said ill patient.