Stuart Winter;STC.UNM;Bridget Wilson;Michael Erasmus;Michael Horowitz
发明人:
Wilson, Bridget S.,Winter, Stuart S.,Erasmus, Michael Frank,Horowitz, Michael
申请号：
AU2016215110
公开号：
AU2016215110A1
申请日:
2016.02.05
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
This disclosure describes the identification of pre-B Cell Receptor (pre-BCR) antagonists and the use of pre-BCR antagonists as a targeted therapy. The compositions and methods generally involve a composition that includes a pre-B cell receptor (pre-BCR) antagonist and is engineered for expression as a T cell chimeric receptor. In some embodiments, the pre-BCR antagonists can include an anti-pre-BCR antibody.
