Indiana University Research and Technology Corporation
发明人:
Zlotnick Adam,Loeb Dan
申请号：
US201214232377
公开号：
US9968650(B2)
申请日:
2012.07.13
申请国别(地区):
美国
年份:
2018
代理人:
Faegre Baker Daniels LLP
摘要：
This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective virion production. The dominant negative structural protein mimics antiviral drugs through structural and biochemical interactions during virus assembly. An effective gene therapy model for chronic viral infected diseases is proposed in this disclosure, as represented by HBV Cpdominant1 to clear viral infection.
