The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I；wherein hatched lines represent the alpha configuration, a triangle represents the beta configuration and a dotted line represents the presence or absence of a double bond；A and B are CH2；D represents a covalent bond or CH2, O, S or NH；X is CO2R, CONR2, CH2OR, P(O)(OR)2, CONRSO2R SONR2 orY is O, OH, OCOR<；2>；, halogen or cyano；Z is CH2 or a covalent bond；R is H or R<；2>；；R<；1 >；is H, R<；2>；, phenyl, or COR<；2>；；R<；2 >；is C1-C5 lower alkyl or alkenyl and R3 is benzothienyl, benzofuranyl, naphthyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR2, CO2R and OR.
