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P-TOLUENESULFONATE POUR INHIBITEUR DE KINASE MEK, FORME CRISTALLINE DE CELUI-CI ET PROCEDE DE PREPARATION DE CELUI-CI
专利权人:
JIANGSU HENGRUI MEDICINE CO.; LTD.
发明人:
WU, GUAILI,GAO, XIAOHUI,BIAN, LIN,JIA, JUNLEI
申请号:
CA2978796
公开号:
CA2978796A1
申请日:
2016.03.08
申请国别(地区):
CA
年份:
2016
代理人:
摘要:
Disclosed are a p-toluenesulfonate for an MEK kinase inhibitor, and a crystalformthereof and a preparation method therefor. Specifically, disclosed are a2-((2-fluorine-4-iodophenyl)amino)-1-methyl-4-((6-methylpyridine-3-group)oxygroup)-6-carbonyl-1,6-dihydropyridine-3-formamide p-toluenesulfonate (a compoundrepresented by formula (I)), and an I-form crystal and a preparation methodtherefor.The obtained I-form crystal of the compound represented by formula (I) hasgoodcrystal form stability and chemical stability, and a used crystallizationsolvent has lowtoxicity and low residue and can be better used in clinical treatment.(see formula I)
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