PROCÉDÉ DE PRÉDICTION DE LA RÉPONSE À UN TRAITEMENT PAR UN ANTAGONISTE DE CRHR1 ET/OU UN ANTAGONISTE DE V1B CHEZ UN PATIENT ATTEINT DE SYMPTÔMES DE LA DÉPRESSION ET/OU DE L'ANXIÉTÉ
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人:
申请号：
EP19190295.6
公开号：
EP3623483A1
申请日:
2014.06.16
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
The present invention relates to a method for predicting a treatment response to a corticotropin releasing hormone receptor type 1 (CRHR1) antagonist and/or a vasopressin receptor 1B (V1B) antagonist in a patient with depressive and/or anxiety symptoms. The present invention furthermore relates to a V1B receptor antagonist and/or CRHR1 antagonist for use in the treatment of depressive symptoms and/or anxiety symptoms in a patient. Also, kits, diagnostic compositions, devices and microarrays allowing the determination of the presence or absence of at least one polymorphic variant in the AVPR1B gene in combination with the presence or absence of at least one polymorphic variant in the patient's genome excluding the AVPR1B gene in the nucleic acid sample are described.
