RYAN CHRISTOPHER CLARK;INCEPTION 2 INC.;JASON DUARTE JACINTHO;AUSTIN CHIH-YU CHEN;JILL MELISSA BACCEI;BRIAN ANDREW STEARNS;YALDA MOSTOFI BRAVO;NICHOLAS SIMON STOCK
发明人:
NICHOLAS SIMON STOCK,AUSTIN CHIH-YU CHEN,YALDA MOSTOFI BRAVO,JASON DUARTE JACINTHO,JILL MELISSA BACCEI,BRIAN ANDREW STEARNS,RYAN CHRISTOPHER CLARK
申请号：
IL23937215
公开号：
IL239372A
申请日:
2015.06.11
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The invention disclosed herein is directed to compounds of Formula I and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a therapeutically effective amount of a selective PPAR&alpha； antagonist. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as HCV infections and HIV infections.
