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TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS
- 专利权人:
- JANSSEN VACCINES & PREVENTION B.V.
- 发明人:
- LANGEDIJK, Johannes,RUTTEN, Lucy,STROKAPPE, Nika,TRUAN, Daphné
- 申请号：
- SG11202000112X
- 公开号：
- SG11202000112XA
- 申请日:
- 2018.07.12
- 申请国别(地区):
- SG
- 年份:
- 2020
- 代理人:
- 摘要：
- 6 19 July 2017 (19.07.2017) EP 17191083.9 14 September 2017 (14.09.2017) EP 18158862.5 27 February 2018 (27.02.2018) EP 18178358.0 18 June 2018 (18.06.2018) EP (71) Applicant: JANSSEN VACCINES & PREVENTION B.V. [NL/NL]； Archimedesweg 4, 2333 CN Leiden (NL). (72) Inventors: LANGEDIJK, Johannes, Petrus, Maria； Archimedesweg 4-6, 2333 CN Leiden (NL). RUTTEN, Lucy； Archimedesweg 4-6, 2333 CN Leiden (NL). STROKAPPE, Nika, Mindy； Archimedesweg 4-6, 2333 CN Leiden (NL). TRUAN, Daphne； Archimedesweg 4-6, 2333 CN Leiden (NL). (74) Agent: VERHAGE, Richard, A et al.； Archimedesweg 4-6, 2333 CN Leiden (NL). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: TRIMER STABILIZING HIV ENVELOPE PROTEIN MUTATIONS (57) : Human immunodeficiency virus (HIV) envelope proteins having specified mutations that stabilize the trimeric form of the envelope protein are provided. The HIV envelope proteins described herein have an improved percentage of trimer formation and/or an improved trimer yield. Also pro
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