Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
THE UNIVERSITY OF IOWA RESEARCH FOUNDATION;ALDERBIO HOLDINGS LLC
发明人:
Kovacevich, Brian Robert,Garcia-Martinez, Leon F.,Latham, John A.,Russo, Andrew F.,Kaiser, Eric A.,Recober, Ana,Kuburas, Adisa,Raddant, Ann C.,Smith, Jeffrey T.l.
申请号：
NZ71770012
公开号：
NZ717700A
申请日:
2012.05.21
申请国别(地区):
NZ
年份:
2018
代理人:
摘要：
Disclosed is a method of assessing the potential in vivo efficacy of a candidate anti-CGRP antibody or anti-CGRP antibody fragment, anti-CGRP receptor antibody or anti-CGRP receptor antibody fragment, or a polypeptide comprising a fragment of CGRP or CGRP receptor for treating photophobia or light aversion, comprising determining whether the candidate inhibits light aversive behaviour in a nestin/Ramp1 rodent administered CGRP compared to a rodent administered CGRP in the absence of the candidate.
