GAVAI, ASHVINIKUMAR V.,DELUCCA, GEORGE V.,OMALLEY, DANIEL,GILL, PATRICE,QUESNELLE, CLAUDE A.,FINK, BRIAN E.,ZHAO, YUFEN,LEE, FRANCIS Y.
申请号：
PH12015500414
公开号：
PH12015500414A1
申请日:
2015.02.26
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
Disclosed are compounds of Formula (I) and/or salts thereof: (I) wherein R1 is CH2CH2CF3 R2 is CH2CH2CF3 or CH2CH2CH2CF3 R3 is H, CH3, or Rx R4 is H or Ry Ring A is phenyl or pyridinyl and Rx, Ry, Ra, Rb, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer or as prodrugs of such compounds.
